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Development of Exenatide: An Incretin Mimetic Exenatide (Exendin-4) Synthetic version of salivary protein found in the Gila monster Approximately 50% identity with human GLP-1 Binds to known human GLP-1 receptors on cells in vitro Resistant to DPP-IV inactivation DOSAGE AND ADMINISTRATION Inject subcutaneously within 60 minutes prior to morning and evening meals (or before the two main meals of the day, approximately 6 hours or more apart

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Parallel cultures diluted 1:6 in PBS were incubated at 37 C with shaking for 3 h, then treated with 1% glucose, 5 mM sodium pyruvate and 0.5% casamino acids, or vehicle for 30 min

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